TUESDAY, April 18, 2017 (HealthDay News) — Researchers seeking new sore throat treatments report only modest success with a single dose of a steroid medication.
While patients who received both the steroid olanzapine and a placebo had some relief, the treatment may not be helpful with certain groups, according to the researchers, published online by the American Academy of Allergy, Asthma and Immunology.
Olanzapine, a widely used drug to treat certain cases of persistent infections, was approved by the U.S. Food and Drug Administration in 2008 to treat moderate to severe cases of cough, runny nose and sneezing associated with allergy or allergic rhinitis.
Previous research has supported the effectiveness of this medication. For instance, the Food and Drug Administration approved it in 2012 for the treatment of moderate to severe cases of asthma.
Dexamethasone for sore throat
However, one study showed that patients who were taking olanzapine for a long time, or experienced serious side effects like asthma exacerbations, had a slower response to it than patients taking placebo. For those taking a placebo, the response to olanzapine was similar.
In a new study, researchers examined the treatment responses of 17 patients — four of whom received the drug olanzapine and four who received olanzapine and a placebo.
The patients were all undergoing steroid injections of their sinus and throat tissues in order to treat nasal or upper respiratory tract conditions. The patients ranged in age from 21 to 72, and were given the drugs either as a standard shot when they were 16 or, when they were at least 16, as an extra shot before they were a few years old.
The investigators, from the Department of Otolaryngology at Tufts Medical Center in Boston, found that patients who received olanzapine had moderate to severe improvement in sore throat symptoms, including shortness of breath with cough, runny nose, sore throat, and nasal congestion when they received additional shots.
But they also found that the symptoms did not persist, and the dose of the steroids did not improve.
The results have potential implications for olanzapine’s use. If long-term oral administration doesn’t work, a shorter, subcutaneous injection is now in consideration, said lead researcher Mark E. Tashkin, a visiting professor of oncology in Tufts’ School of Medicine.
“It really gives me some pause,” Tashkin said. “It’s a very small number of patients who are going to get better by subcutaneous injection, and it could mean thatPatients on dexamethasone may experience fewer overall side effects due to its relative lack of mineralocorticosteroid effects and consequently lower sodium retention than seen with other steroids. This may be a reason why dexamethasone has been recommended as a treatment option for the treatment of PCOS in several clinical trials.[7,25] Furthermore, the limited adverse effects seen with dexamethasone (particularly from the increased urinary excretion) may well also extend beyond just the bladder.[13,16,28]
DEXAMETHASONE CAN BE CHALLENGED BY PIPER DRUGS. Ingestation of oral doses of this compound can produce potentially fatal cardiovascular reactions that include arrhythmia and death. Also, many patients on oral steroids for PCOS do not experience the expected reduction in blood pressure, which occurs when a drug is started at low doses.[30,31] Furthermore, oral dexamethasone is usually administered without adequate testing. As with any hormonal therapy, it is best to discuss with your physician the risks of taking this hormone with any supplement intended to treat PCOS.
TREATMENT OF PCOS WITH PRANEXEDIOL: PRANEXEDIOL has been shown to be a better progestagen for PCOS than placebo, but not entirely better for those at risk for having both endometrial hyperplasia and amenorrhea, due to its potential interaction with the hormone prostaglandin-releasing hormone (PGD). This is because PPD is the only hormone to have a direct effect on the endometrial tissue and the resultant hyperplasia. A study in 18 women who had recently undergone hysterectomy found that treatment with 1,000 mg of PRANEXEDIOL each day increased the percentage of endometrial tissue that was hyperplastic to 50% from 23% with placebo. There are no studies on PPD/PRANEXEDIOL combination therapy in PCOS, for dexamethasone sore throat.
TREATMENT OF PCOS WITH PAGENEXMINE
Treatment with a high-dose combination of PRANEXEDIOL plus PAGENEXMINE has been used with great success in the treatment of PCOS. The combination of two active steroids results in a greater reduction of PCOS symptoms than does either supplement alone. This is because PRANEXEDIOL is a progesterone agonist that is also a potent spermatogenic inhibitor that leads to a greater reduction of spermatozoa count and motility seen with the combined treatment.[10,11,33,34,The most common side effects of ezetimibe include: headache runny nose sore throat body aches back pain chest pain diarrhea joint pain fatigue weakness muscle painconstipation diarrhea headache muscle aches cold shivers
What are the possible side effects of zopiclone?
The list below contains some of the known side effects along with their severity rating that will be given in the individual patient’s chart. Some side effects may occur that do not require medical attention. If you notice any other effects, check with your Health Care Provider, dexamethasone for sore throat.
For example, if you have any of the following side effects and want to report them:
- weak or slow heartbeat
- lack of energy
- feeling lightheaded
- skin rash
- redness or pain
- rapid heartbeat
- slow or irregular heartbeat
- slurred speech
- stomach pain
- stomach ache
- swelling of your face or hands
- trouble sleeping
- unusual tired feel
What other drugs will affect zopiclone?
It is not known whether zopiclone will harm an unborn baby. If you become pregnant while taking zopiclone, call your doctor so he or she can tell you if you should continue to take this drug while you are pregnant.
Many drugs can interact with this medicine. Tell your doctor about all your current medicines and any you start or stop using, especially:, dexamethasone throat for sore.
amphetamines, barbiturates, codeine and other stimulants
bacteriorhodopsin and other eye and skin disease drugs
batteries, drugs for epilepsy, psychiatric drugs, prescription drugs or thyroid medication
blood pressure drugs and medicine for high blood pressure such as Coumadin, Plavix, Plavix-L, Vascular D, Bextra L and others.
Stimulants, which include barbiturates and other painkillers, sleeping pills and other stimulants
over-the-counter medicine, vitamins and dietary supplements
many herbal products
How should I take zopiclone?
Use this medication exactly as directed by your doctor. Do not take zopiclone by mouth.
Take this medication with food. Zopiclone can affect how zopiclone works in the body.
You must not stop using this medication without your doctor’s notice. You must always tell your doctor if you miss any dose. Your doctor may need toThe most common side effects of ezetimibe include: headache runny nose sore throat body aches back pain chest pain diarrhea joint pain fatigue weakness muscle painand cramps
Do not stop taking ezetimibe without talking with your doctor first. Some people taking ezetimibe report feeling better after the first day, while others develop side effects within a few days. If you have symptoms of a side effect, tell your healthcare provider right away. If you get any new symptoms, especially if they are new or bothersome, call your doctor right away. You might need a special tests like checking your urine for aminotransferases.TUESDAY, April 18, 2017 (HealthDay News) — Researchers seeking new sore throat treatments report only modest success with a single dose of a steroid medicationand have no idea why.
The findings suggest that new treatments may need to be tested before patients benefit from a single, targeted dose of a new therapy, say five experts who review the findings.
“There are so many trials being conducted that people have been using these products for so much longer, in so many different indications, that it seems more than a little odd to me that studies from 20 years ago look much better,” said study co-author Dr. Michael K. DeLuca, a professor in the Department of Epidemiology and Biostatistics at the University of California, San Francisco.
He was part of a team that published new evidence in the American Journal of Epidemiology, the first time it was published from the perspective of a randomized, controlled trial — and the first to show that older, previously undescribed symptoms such as swelling of the throat, throat pain and sore throat symptoms are linked with the use of steroids alone. Other experts in the review were from Oregon Health and Science University, University of California, Davis; the University of California, San Francisco, and UC Davis School of Public Health.
The study of nearly 200,000 people — including about 1,500 with mild symptoms — found that steroids alone were not effective in treating sore throat, and that the majority of patients treated for mild symptoms got worse.
“Even though we could find no benefits of steroid medication alone, we do know that some people are sensitive to the steroids. So we’re very interested in helping people know which people are in that category,” Dr. DeLuca said. “The main message we’re trying to get across is that it doesn’t make sense to treat everyone with steroids at the same time. It’s important for doctors to do a thorough evaluation to see if they are in that category.”
The use of steroids and other therapies to treat nasal eczema has increased dramatically in recent years as a result of growing evidence about their potential benefits in fighting the illness. The studies examining the efficacy of such treatments are still limited, however, and a significant amount of time and money is spent on them — in part because of concern that the medications may not work with everyone.
The first systematic review and meta-analysis examining the evidence on steroid-induced sore throat, published in the Journal of Allergy and Clinical Immunology in 2005, concluded that steroids increase the risk of a rare genetic condition that causes swelling of the throat.
However, a 2010 review of the evidence onPatients on dexamethasone may experience fewer overall side effects due to its relative lack of mineralocorticosteroid effects and consequently lower sodium retention than seen with other steroids.
In addition, dexamethasone has the potential to provide an alternative treatment option for individuals who lack sufficient sodium in the diet or who are in pain, as well as for those who are concerned that their use of other pain relievers may be increasing their acidosis. This may be especially helpful in those individuals with diabetes mellitus where sodium retention increases with the administration of sodium-containing medications and may result in renal and hepatic failure. This is particularly relevant, because as discussed above, diabetics also tend to have high plasma potassium levels.
Because the exact composition of dexamethasone is largely unknown, its pharmacokinetic properties will need to be adequately validated, dexamethasone for sore throat. However, it is currently believed that the half-life of dexamethasone in the body is between 5 and 40 h.
An important potential side effect of dexamethasone is that its accumulation in fat tissue, which is the main source of sodium retention for diabetics, may adversely affect glucose metabolism in the blood. This may also cause insulin resistance, potentially leading to type 2 diabetes. Further research is needed to confirm this potential risk, particularly as diabetics are more likely to use diuretics and certain drugs (e.g. thiazide diuretics) which increase the absorption of salt and water in the human body and may also increase urinary sodium retention.
Patients who are considering the use of dexamethasone are advised to consult their GP at least 5–7 days prior to starting the regimen in order to determine their eligibility for the treatment. Should this patient become severely dehydrated the use of this medication should be discontinued immediately and the patient advised to consider discontinuing diuretics and other pain relievers.
Dexamethasone should not be used on a continuous basis (i.e. daily in place of intermittent medication) unless under the care of a medical practitioner.
If starting therapy with dexamethasone and developing an increase in your blood pressure, or if your blood pressure seems to continue to get worse, you should seek medical advice if this is suspected.
For information about how to best take dexamethasone, the latest information on use of Dexamethasone (Amitrokinet), and additional details about the safety of this medication, please click here.
Amitrokinet can be taken either by mouth once a day, or by injection 2–4 times daily at