Unfortunately, this abusive use of anabolic-androgenic steroids has given testosterone replacement therapy a bad rap due to symptoms of too much testosterone and other chemicals in steroidsand their interactions with insulin and the pancreas. However, the use of testosterone replacement therapy is not only safe if done correctly, it can actually be beneficial compared to what many testosterone replacement therapies offer.
The benefits of testosterone replacement therapy include the following:
Better sleep: A study of 578 men in the United Kingdom found that men who used testosterone replacement therapy were as efficient and more active than their testosterone replacement therapy-naïve counterparts (1). These men showed significantly improved sleep patterns, which has been shown several other studies to be true. In these men taking testosterone replacement therapy, testosterone was shown to improve overall sleep quality, which in turn decreases overall stress and promotes healthy sleep patterns while preventing obesity.
Deeper sleep: Studies found that men with testosterone replacement therapy had a lower incidence of sleep disturbances (2).
Improved mood: The link between testosterone and mood has been shown in studies and is known to be true in men with low testosterone or low testosterone levels alone. One study found that men who took testosterone and other anabolic-androgenic steroids were less likely to exhibit a depressive attitude than men who took placebo. When it comes to testosterone replacement therapy, the benefits aren’t always apparent in men.
Better brain function: There’s mounting evidence to confirm that testosterone causes a significant increase in the level of a certain neurotransmitters, which is an essential function of the human brain to perform a wide variety of important mental functions. This neurotransmitter increase in testosterone decreases the activity of these neurotransmitters, resulting in a decrease of memory, concentration, and mental stability (2). In other words, testosterone promotes brain functionality in many ways.
Better quality blood flow: In men taking medications that interfere with testosterone production, symptoms can include decreased sex drive (3). Many testosterone replacement therapies help decrease the symptoms of a mood disorder or improve mood with one medication being taken per day. This is good for men who may experience depression because they’re not able to achieve the optimal level of testosterone with the right medication.
These findings aren’t the only benefit of testosterone replacement therapy. There are other benefits you might not have realized. For example:
Better performance in the gym: One of the most interesting aspects of testosterone replacement therapy to me is how successful it has been in athletes. This is because it helps make them stronger and more athletic due to the increase in muscle mass. The increase in muscle mass has been associated with increased testosterone levels and muscle growth. A study of 3200 participants showedTestosterone Cypionate Injection, USP is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone. The USP has been used in Europe to treat hypogonadism. It has an extended duration of use, can be injected daily as an intramuscular injection and can be administered on an as needed basis to prevent adverse effects. USP has been licensed in Canada. In the US, for the evaluation of serum testosterone, USP is also associated with a higher risk for adverse reactions, such as hyperthyroidism, diabetes and adrenal insufficiency. USP can impair liver and kidney function. It may induce hypopituitarism in some patients when administered chronically, and there is concern that it may impair bone age. USP should be administered on an as needed basis if hyperthyroidism exists. USP does not always maintain an adequate level of serum testosterone in patients who are on the treatment course of a disease associated with the deficiency of endogenous testosterone. However, when it is a contraindication for use of the USP, administration of testosterone in combination with estradiol or progesterone is suggested. USP may also cause a decrease in libido and weight gain in elderly patients with low testosterone levels who were on replacement therapy without side effects. The long term use of USP without medical indication should be carefully monitored. USP has been found to promote prostate disease. However, although studies have demonstrated that it is an adjunct to standard of care for patients with low testosterone levels, it is not approved to treat low testosterone. USP, when used concomitantly with oral testosterone for the treatment of hypogonadism, is probably of less direct importance in patients with low testosterone levels, since they generally have enough testosterone to enable functional testosterone production, and USP may not be required for such patients. However, it may increase the risk of erectile dysfunction in normal age men and may affect reproductive function. USP may increase the incidence of prostate cancer in those with hypogonadism.The half-life of testosterone cypionate (test C) is 12 days compared to that of testosterone enanthate (test E), which is 10-11 days, with not much of a large differencein the pharmacokinetic values. Testosterone increases concentration of DHT in the gonads more than either testosterone cypionate or enanthate, due to a greater DHT/DHT ratio in the testis (approximately 5µM/L relative the control).
While testosterone may possess some potency at stimulating DHT production, it does not seem to exert these effects to the extent that testosterone enanthate has in the genital tract and prostate in rats due to the lack of a larger difference in potency between the two.
3 Safety and Toxicology
Testosterone injections have been found to possess no documented adverse effects on humans (and even less so than placebo), although some rare cases have been noted in the literature. Because of the low doses that are typically administered to humans (and the higher doses typically given to experimental animals), most of the human reports of toxicity come from injections with low doses of testosterone and/or synthetic DHT.
Due to the limited safety data and the relatively low dosages used in vivo, it is difficult to extrapolate from these findings to human health. However, anecdotal evidence suggests that some effects of the male hormone testosterone may occur; however, this does not rule out the possibility of serious side effects in humans. As the only human study published specifically looking at this topic (Hodges et al. 2003), the study itself had very high drop-out rates; for this reason it is difficult to draw firm conclusions; nonetheless, we can draw a few thoughts from the study, symptoms of too much testosterone cypionate.
First, it was determined that the human subjects receiving testosterone did not experience major adverse effects associated with the administration of testicular replacement therapy. A more typical case of adverse effects associated with testosterone administration was seen in men given 200-300 mg per day of testosterone cypionate as a placebo for 2 years and in one participant received 100 mg per day for 6 years. Both of these individuals experienced signs of increased prostate volume but more so in the former in response to testosterone; as seen with other methods of testosterone administration (cypionate, injections, and dietary supplements) this increase is known to be associated with the increase in serum DHT and decreases in testosterone.
Second, despite the extremely high drop-out rate of the study, the researchers also concluded that there is a lack of evidence for an increased frequency of adverse events with testosterone given by itself (only oneUnfortunately, this abusive use of anabolic-androgenic steroids has given testosterone replacement therapy a bad rap due to symptoms of too much testosterone and other chemicals in steroids. Not surprisingly, many testosterone-free testosterone products have become popular; while this trend also results in an increased risk for heart disease, stroke, certain cancers, and even death. This means the long-term health effects of testosterone may not be all that great. The effects of testosterone supplementation are well know, however, and it does seem that in many cases, testosterone supplementation can be quite beneficial. However, using too much testosterone could have side effects that could include anxiety, depression, and even suicidal behavior.
I understand that testosterone supplementation is a controversial topic. Some people feel it has a negative effect on their performance and quality of sleep. However, if you’re thinking about testosterone supplementation for general performance, this is still a topic to consider. The benefits of taking testosterone supplements can include the ability to reduce your risk for various diseases, such as heart disease, high blood pressure, and even certain cancer types. In my opinion, the benefits of this treatment should be enough to justify this type of supplementation. With this in mind, it might just be time to revisit your steroid cycle routine.
The Bottom Line
Many people who decide to take a testosterone supplement want to take a testosterone supplement to feel “full”. However, many have reports that this can actually be detrimental for their health. Therefore, if you’re thinking about taking a testosterone supplement, make sure to take one that is safe and doesn’t cause any problems. And don’t forget, take your testosterone just enough to keep your levels in check, but not so much that you’ll get sick. Finally, know that even if you’re not going on the testosterone regimen, you still need testosterone to maintain weight loss and other necessary processes of metabolism.Testosterone Cypionate Injection, USP is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosteronesuch as chronic or acute sexual or urinary dysfunction requiring the presence of testosterone therapy or when the patient is receiving an irreversible androgen deficiency.
Injectable testosterone is contraindicated in children less than 18 years old
Cocaine Use, Injectable
Users of cocaine may experience some mild effects, including:
Muscle tension and fatigue
Tingling in the fingers.
Severe allergic reactions can occur. Use with caution in children under 18 years with a severe or life-threatening allergy to tobacco and should be used with caution in children older than 18 years.
Cocaine can cause changes in blood pressure. Monitor patients closely.
Cocaine abuse may increase your risk of heart attack and heart failure.
Cocaine use may enhance the euphoria, sedation, and stimulation characteristic of drugs of abuse such as prescription and illicit opioids. When cocaine is used in combination with other substances, the risks of dependence and addiction may exceed the benefits.
Users of cocaine are more likely to be involved in violent crimes and violent accidents, much cypionate of too symptoms testosterone.
Cocaine and Heroin use, Injection
Users of heroin are usually not dependent on narcotics. They often report a much more intense “high” when they use heroin than when they use cocaine.
Heroin usually lasts longer on some types of heroin.
Methamphetamine users may experience a more intense euphoric, relaxing, and sedatives effects than users of cocaine. Methamphetamine may also produce side effects that are more severe than those of cocaine.
Sudden, unexpected increase or sudden decrease in body temperature may indicate an overdose.
Symptoms of too much testosterone cypionate
Sudden, unexplained weight loss during the first few hours after use can indicate an overdose.
Heroin may cause loss of control over the muscles that control breathing and blood pressure.
An overdosing patient may experience respiratory arrest, coma, cardiac arrest, or even death.
If you suspect that your child has ingested, is using, or is about to consume any drug not listed above, call and notify 911 immediately.
Addiction and dependence
Addiction and dependence of any drug can be life threatening. Even the mildest of addictive substances can lead to addiction or dependence. Addictive substances include:
Opioids (morphine, morphine), too testosterone cypionate of much symptoms.
Other opiates or illicit depressants
These drugsThe half-life of testosterone cypionate (test C) is 12 days compared to that of testosterone enanthate (test E), which is 10-11 days, with not much of a large differencein duration. Although testosterone enanthate may be more potent, testosterone cypionate is a potent stimulator of the adrenal gland when it is used at low doses. This study showed that testosterone cypionate was more potent for suppression of CCL8 than that from testosterone enanthate.
“We believe our results demonstrate that testosterone cypionate does not possess as high an impact on CCL8 as testosterone enanthate,” he said. “There is a much more promising effect from testosterone cypionate than the effect that was shown with enanthate treatment.”
Testosterone cypionate is a prescription anabolic steroid that targets the growth hormone (GH) receptor. GH, like progesterone and estrogen, also stimulates the adrenal cortex and the pituitary gland, and its breakdown results in increased CCL8 levels. In a study by Poulin & Aerts (2004), testosterone cypionate led to a 40% increased growth hormone releasing hormone (LH-HRH) in men (mean increase of 13.7 +/- 0.7 pg/mL) with an average increase of 5.5 +/- 0.3 pg/mL.
The other study looked at other GH receptors and concluded that when administered orally, GH is not increased by any pharmacological drugs used for GH stimulation. In the study by Poulin & Aerts (2004), testosterone cypionate increased the release of GH by 2.2 +/- 0.2 pg/mL in 5 healthy volunteers who took it 2 times a day for 12 weeks. With testosterone enanthate, that was the case with the authors of the study. That is, testosterone cypionate had a greater effect on GH secretion and the LH-HRH response than that found with testosterone enanthate. There is conflicting evidence on whether these two hormones can be stimulated at a similar rate, but both could be stimulated to a similar degree by testosterone cypionate.
Testosterone cypionate is sold under the brand names TCL, which is the European brand name, and CYP-54320, which is the generic name for it.
T. Poulin, S. Jorgensen, O. Aerts, J. Söderqvist, “Anandamide and GH secretion: Effects of a competitive and nonselective inhibitor of the anabolic-androgen receptor on human and rabbit GHUnfortunately, this abusive use of anabolic-androgenic steroids has given testosterone replacement therapy a bad rap due to symptoms of too much testosterone and other chemicals in steroidsthat affect the body. In this article we’ll examine the possible dangers of high doses of testosterone, its effects and alternatives to it.
Why do steroids matter? In order to understand the issue of testosterone replacement therapy we need to understand the problem with the way we have structured our approach to health care since its inception.
The first step in creating a health system is understanding what patients are suffering from. This is what doctors used to do when treating people with disease, they would consult with the patient to discover their problem, evaluate the symptoms and their chances of recovery based on their medical history. It’s called “surgical de-hormoneization,” or the “medicalization of disease.”
From my doctor’s books I learned that the use of testosterone replacement therapy was a serious problem for many patients, symptoms of too much testosterone cypionate. I learned I had to ask patients why their symptoms had not resolved. Since so many patients were telling the same story I began to look into these patients’ cases from a doctor’s standpoint, using a holistic approach.
From my research and on-the-ground investigation, I believe patients use steroid injections and testosterone-replacement therapy when they are experiencing serious health problems and are afraid that medication may not resolve their symptoms. However, I do agree that these patients may be taking steroids that are not appropriate for their health or in some cases are already taking steroids that have been found to have adverse effects, or are taking combinations of medication, which would not do their health the way it is supposed to.
The second step in creating a well-functioning health system is acknowledging that we have the potential to make a significant difference to the health of our patients. We need to realize that every day the patients we take care of suffer through debilitating medical problems and can only imagine what they are going through every few months. For this reason it is a priority to get the necessary information from as many different sources as possible when treating patients, in this case, steroid injections and testosterone-replacement therapy for those patients with severe health conditions.
Since the introduction of testosterone replacement therapy, the way that the American medical community approach hormone therapy for health issues has changed. For years physicians thought that hormones were a way to manage symptoms, but I have come to believe that it may be time to move away from the medicalization of disease and begin looking more at the way hormones may be part of a holistic health systems.
The best way to address the issue of testosterone replacement therapy without using medicine is by looking at theTestosterone Cypionate Injection, USP is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosteroneproduction.
The dosage of testosterone propionate should be carefully regulated to assure the safety of users. Daily dosages of 15 mg should be taken for 2 to 3 months. Testosterone propionate, USP is not recommended for use as an oral contraceptive.
The pharmacokinetic properties are similar to that of the testosterone propionate tablet. Testosterone propionate, USP is not readily bioavailable in human plasma. In general, however, plasma testosterone levels are highest when administered concomitantly with insulin, when a prolonged and adequate supply of insulin is in effect, and when testosterone is administered in a large dosage for a prolonged time.
The effect of testosterone propionate, USP on the thyroid is unknown.
Treatment of men who require testosterone replacement therapy should include, but not be limited to, a decrease of the dose of the testosterone propionate product administered subcutaneously, concomitantly with a reduction in dosage administered intramuscularly, to reduce the chance of adverse effects.
Because of their rapid action, testosterone propionate, USP may pose a risk of adverse side effects, such as cardiac arrhythmias and syncope.
Interactions with Medications
It should be noted that if testosterone propionate is used with other medications that alter the synthesis, metabolism, or release of testosterone (for example, those that may stimulate the production of androgens), the interaction may result in an increased risk of adverse side effects.
Adverse reactions involving testosterone propionate, USP in males who are unable to take concomitant medications containing testosterone and have a reduced capacity for the conversion of testosterone into dihydrotestosterone (DHT ) are uncommon and are generally mild. Adverse reactions that are reported to be of concern include:The half-life of testosterone cypionate (test C) is 12 days compared to that of testosterone enanthate (test E), which is 10-11 days, with not much of a large differencein the half-lives of testosterone cypionate (test C) and testosterone enanthate (test E). Testosterone is released into the circulation within 24 hours and its half-life depends on the method of administration. Testosterone cypionate (test C) is absorbed quickly and is rapidly converted to testosterone by protein metabolism. Testosterone enanthate (test E) is a slower release steroid and can have much more of an effect on blood testosterone levels than does a shorter term (30 minutes) method of administration of testosterone enanthate or testosterone cypionate. For a comparison of testosterone and other androgens to understand the effects of testosterone administration see the section: androgen action. The dose of testosterone is very important in regards to the effect of testosterone on androgen levels. This is why it is essential to monitor serum testosterone levels in individuals taking testosterone.
How does testosterone in a person affect the appearance of their skin and body?
Testosterone has a powerful effect on the skin and body. It is very often referred to as the ‘male hormone’. T he effects of testosterone on skin are much like steroids and are similar in what they do on bone and muscle, but are much more pronounced. Testosterone is involved in many important skin functions like hair growth, hair color, wrinkles, acne, and hair thickness.
Testosterone can also increase your bone and muscles growth rate when the testosterone level is high enough. This happens because testosterone increases the production of growth factors from the IGF-1 gene. These hormone dependant growth factors stimulate the growth of new bone and muscle tissue. As well, the growth hormone produced by testosterone is important in the formation of new white hair and the new cell proliferation in the hair follicle.
In addition, testosterone increases the growth of your hair follicle, which gives it a greater density and volume.
Testosterone and acne
Testosterone has a strong influence on skin and the acne-prone skin types; it is extremely important when selecting the right types of products to treat acne that contain testosterone (or its metabolites). It cannot be overstated that acne is a severe acne condition and a great part of the overall problem associated with acne is caused by the abnormal levels of the androgens (androgens can also cause cancer) present in a person’s body, as well as the high level acne produced by the person’s environment (e.g. acne with excessive oils, greaseless foods, lack of moisturizer, etc.). It